Effect of Resveratrol against Cisplatin-Induced Clastogenicity

Günsel BİNGÖL, Mehmet Doğan GÜLKAÇ, Meltem Özlen DİLLİOĞLUGİL, Aylin Özön KANLI


Cisplatin (cDDP) is a widely used chemotherapeutic agent for treating a variety of cancers. The drug can also induce chromosomal aberrations (clastogenicity) in healthy cells in cancer patients. Resveratrol (RES) is a natural polyphenol and has been claimed that it has a high protection against clastogenicity. In this study, we aimed to investigate the effect of resveratrol on cDDP-induced chromosome aberrations in bone marrow cells of Wistar albino male rats. Six groups with six animals in each were orginized. Two different resveratrol doses (12.5 ve 25 mg/kg bw) were used and injected intraperitoneally (ip). Resveratrol doses were applied 5 times during the 24 h study period to coincide with the schedule for the cDDP-RES combination groups. With regard to the experimental schedule, cDDP-RES groups received cDDP (5 mg/kg bw) and RES at either 12.5 or 25 mg/kg bw, 30 min before, concurrently, and then at every 6 h after cDDP administration. RES caused a significant reduction in the frequency of chromosome aberrations compared to those induced with cDDP alone. As a result, repeatedly applied RES doses (12.5 or 25 mg/kg bw) during 24h caused statistically significant reduction at the frequency of cisplatin induced chromosome aberrations. In conclusion, it is evaluated that resveratrol can be an option as an adjuvant treatment.


Cisplatin, Chromosome Aberration, Resveratrol, Anticlastogenic

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