Variation in FABP4 gene associated with the morphometric traits in Albanian sheep

Anila HODA, Luan HAJNO, Lorena HYSI, Xhiliola BIXHEKU


Fatty acid-binding protein 4 (FABP4) participates in fatty-acid transportation and variation in the gene has been reported to affect meat quality and growth traits in sheep. The aim of the study was to identify the association of variation in the intron 3 of FABP4 gene in an Albanian sheep population with morphometric traits. The analysis covered a total of 70 individuals randomly selected.  The molecular analysis detected two alleles A and G with frequencies 0.707 and 0.293 respectively and three genotypes. All morphometric traits have a significant positive correlation. The fixation index was -13.8% indicating a moderate level of outbreeding. The results indicated no significant effect of this locus on morphometric traits.


body measurements; correlation; genetic diversity; General Linear model;

Full Text:



Ardicli S, Dinçel D, Samli H and Balci F. 2017 Association of single nucleotide polymorphisms in the LEP, CAST, CAPN1, GHR, FABP4 and DGAT1 genes with fattening performance and carcass traits in simmental bulls. .

Ardicli S, Samli H, Vatansever B, Soyudal B, Dinçel D and Balci F. 2019 Comprehensive assessment of candidate genes associated with fattening performance in Holstein Friesian bulls. Archives Animal Breeding. 62, 9-32.

Botstein D, White RL, Skolnick M and Davis RW. 1980 Construction of a genetic linkage map in man using restriction fragment length polymorphisms. American journal of human genetics. 32(3): 314.

Bozgo V, Hoda A, Hysi L and Papa L. 2020 Genetic polymorphism detection of Casein genes in Albanian local sheep breeds. Livestock Research for Rural Development. 32.

El-Mansy SA, Peris S, Ibrahim A and Nasr A. 2019 Genetic variation in the ovine fatty acid binding protein-4 (FABP4) gene and its association with live performance and carcass traits in egyptian ossimi lambs. Journal of Agricultural Research. 46, 2371-2383.

Hoda A, Ajmone-Marsan P and Hykaj G. 2010 Genetic diversity in albanian sheep breeds estimated by AFLP markers. Albanian Journal of Agricultural Sciences. 9(2):, 23-29.

Hoda A, Bytyqi H, Dobi P and Mehmeti H. 2009 Genetic diversity of Bardhoka breed in Albania and Kosova analyzed by microsatellite markers. Research Journal of Agricultural Science. 41, 218-223.

Hoda, A. and Marsan, P.A. (2012) Genetic Characterization of Albanian Sheep Breeds by Microsatellite Markers. In M. Caliskan, Ed. Analysis of Genetic Variation in Animals. IntechOpen.

Hoda A, Bytyqi H and Bozgo V. 2014 Genetic diversity of sheep breeds from Albania and Kosovo revealed by mtDNA. Journal of Endocytobiosis and Cell Research. 66 69.

Hoda A, and Hajno L. 2021 Body measurements of Bardhoka sheep breed from Albania. Acta Biologica Turcica. 34(3):, 122-127.

Hoda A, Hykaj G, Sena L and Delia, E. 2011 Population structure in three Albanian sheep breeds using 36 single nucleotide polymorphisms. Acta Agriculturae Scandinavica, Section A — Animal Science. 61(1):, 12-20.

Hu Z, Park C and Reecy J. 2018 Building a livestock genetic and genomic information knowledgebase through integrative developments of Animal QTLdb and CorrDB. Nucleic acids research. 47.

Ibrahim A, Tzanidakis N, Sotiraki S, Zhou H and Hickford J. 2019 Identification of the association between FABP4 gene polymorphisms and milk production traits in Sfakia sheep. Archives Animal Breeding. 62, 413-422.

Khalil MH. 2020 Molecular applications of candidate genes in genetic improvement programs in livestock. Egyptian Journal of Animal Production. 57(Suppl. Issue):, 1-23.

Li X, Ekerljung M, Lundström K and Lundén A. 2013 Association of polymorphisms at DGAT1, leptin, SCD1, CAPN1 and CAST genes with color, marbling and water holding capacity in meat from beef cattle populations in Sweden. Meat Sci. 94(2):, 153-158.

Q. Xu, Tang GW, Zhang QL, Huang Y, Liu YX, Quan K, Zhu K and Zhang C. 2018 The FABP4 gene polymorphism is associated with meat tenderness in three Chinese native sheep breeds. Czech Journal of Animal Science. 56, 1-6.

Shafey HI, Mahrous K, Hassan AA, Rushdi HE and Ibrahim M. 2020 Single-nucleotide polymorphisms in FABP4 gene associated with growth traits in Egyptian sheep. Veterinary World. 13, 1126-1132.

Xu QL, Tang GW, Zhang QL, Huang YK, Liu YX, Quan K, Zhu KY and Zhang CX. 2011 The FABP4 gene polymorphism is associated with meat tenderness in three Chinese native sheep breeds. Czech Journal of Animal Science. 56(1):, 1-6.

Yan W, Zhou H, Jiang Hu, Luo Y and Hickford JG. 2018 Variation in the FABP4 gene affects carcass and growth traits in sheep. Meat Science. 145, 334-339.

Yeh F, Yang R and Boyle T. 1999 POPGENE Version 1.32 Microsoft Windows-based freeware for populations genetic analysis. University of Alberta, Edmonton. .


  • There are currently no refbacks.